Inflammation /
Joint

J Agric Food Chem. 2017, 65(19), 3811-3818.

Ameliorative Effect of Ecklonia cava Polyphenol Extract on Renal Inflammation Associated with Aberrant Energy Metabolism and Oxidative Stress in High Fat Diet-Induced Obese Mice.
Eo H, Park JE, Jeon YJ, Lim Y.

Cells. Molecules. 2017, 22(5), 777.

Crude Ecklonia cava Flake Extracts Attenuate Inflammation through the Regulation of TLR4 Signaling Pathway in LPS-Induced RAW264.7
Hwang JH, Kim KJ, Lee BY.

Immunopharmacol Immunotoxicol. 2016, 38(3), 244-252.

6,6'-Bieckol suppresses inflammatory responses by down-regulating nuclear factor-κB activation via Akt, JNK, and p38 MAPK in LPS-stimulated microglial cells.
Kim AR, Lee B, Joung EJ, Gwon WG, Utsuki T, Kim NG, Kim HR.

J Agric Food Chem. 2016, 64(3), 570-578.

Protective Effect of Brown Alga Phlorotannins against Hyper-inflammatory Responses in Lipopolysaccharide-Induced Sepsis Models.
Yang YI, Woo JH, Seo YJ, Lee KT, Lim Y, Choi JH.

J Agric Food Chem. 2015, 63(1), 349-359.

Brown alga Ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress and inflammation by activation of AMPK and SIRT1 in high fat diet-induced obese mice.
Eo H, Jeon YJ, Lee M, Lim Y.

Int Immunopharmacol. 2014, 23, 460-468.

8,8'-Bieckol, isolated from edible brown algae, exerts its anti-inflammatory effects through inhibition of NF-κB signaling and ROS production in LPS-stimulated macrophages.
Yang YI, Jung SH, Lee KT, Choi JH.

Algae 2014, 29(2), 165-174.

Polyphenol-rich fraction from Ecklonia cava (a brown alga) processing by-product reduces LPS- induced inflammation in vitro and in vivo in a zebrafish model.
Kim SY, Kim EA, Kang MC, Lee, JH, Yang HW, Lee JS, Lim TI, Jeon YJ.

Int Immunopharmacol 2014, 22(1), 51-58.

Hemeoxygenase 1 partly mediates the anti-inflammatory effect of dieckol in lipopolysaccharide stimulated murine macrophages.
Yayeh T, Im EJ, Kwon TH, Roh SS, Kim S, Hong SB, Cho JY, Park NH, Rhee MH.

Appl Biochem Biotechnol. 2014, 173(4), 957-967.

Suppression of NF-κB by Dieckol Extracted from Ecklonia cava Negatively Regulates LPS Induction of Inducible Nitric Oxide Synthase Gene.
Choi HJ, Park JH, Lee BH, Chee HY, Lee KB, Oh SM.

Chem Commun (Camb). 2014, 50(86), 13045-13048.

Synthesis of rhodamine-labelled dieckol: its unique intracellular localization and potent anti-inflammatory activity.
Kwak JH, He Y, Yoon B, Koo S, Yang Z, Kang EJ, Lee BH, Han SY, Yoo YC, Lee KB, Kim JS.

Int J Biol Macromol. 2014, 67, 303-311.

Water soluble sulfated-fucans with immune-enhancing properties from Ecklonia cava.
Cao RA, Lee Y, You S.

Asian Pac J Trop Biomed. 2014, 4(7), 529-537.

Jeju seaweeds suppress lipopolysaccharide-stimulated proinflammatory response in RAW 264.7 murine macrophages.
Yang EJ, Moon JY, Kim SS, Yang KW, Lee WJ, Lee NH, Hyun CG.

Carbohydr Polym. 2013, 92(1), 84-89.

Anti-inflammatory effect of fucoidan extracted from Ecklonia cava in zebrafish model.
Lee SH, Ko CI, Jee Y, Jeong Y, Kim M, Kim JS, Jeon YJ.

Food Chem Toxicol. 2013, 59, 199-206.

Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages.
Jung HA, Jin SE, Ahn BR, Lee CM, Choi JS.

Environ Toxicol Pharmacol. 2013, 35(3), 395-401.

Protective effect of phlorotannins from Eisenia bicyclis against lipopolysaccharide-stimulated inflammation in HepG2 cells.
Kang YM, Eom SH, Kim YM.

Inflammation. 2013, 36(2), 259-271.

Phlorofucofuroeckol A Suppresses Expression of Inducible Nitric Oxide Synthase, Cyclooxygenase-2, and Pro-inflammatory Cytokines via Inhibition of Nuclear Factor-κB, c-Jun NH(2)-Terminal Kinases, and Akt in Microglial Cells.
Kim AR, Lee MS, Choi JW, Utsuki T, Kim JI, Jang BC, Kim HR.

Biochim Biophys Acta. 2013, 1830(3), 2820-2829.

The JNK/NFκB pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from Ecklonia cava.
Ahn G, Bing SJ, Kang SM, Lee WW, Lee SH, Matsuda H, Tanaka A, Cho IH, Jeon YJ, Jee Y.

Int Immunopharmacol. 2012, 12(3), 510-517.

6,6'-Bieckol, isolated from marine alga Ecklonia cava, suppressed LPS-induced nitric oxide and PGE(2) production and inflammatory cytokine expression in macrophages: The inhibition of NFκB.
Yang YI, Shin HC, Kim SH, Park WY, Lee KT, Choi JH.

J Agric Food Chem. 2012, 60(36), 9120-9129.

Anti-inflammatory activities of an ethanol extract of Ecklonia stolonifera in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
Lee MS, Kwon MS, Choi JW, Shin T, No HK, Choi JS, Byun DS, Kim JI, Kim HR.

Evid Based Complement Alternat Med. 2011, 2011, 140462.

Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway.
Zhang C, Li Y, Qian ZJ, Lee SH, Li YX, Kim SK.

Mar Biotechnol (NY). 2011, 13, 66-73.

Enzymatic Extract from Ecklonia cava Induces the Activation of Lymphocytes by IL-2 Production Through the Classical NF-kappaB Pathway.
Ahn G, Park E, Lee WW, Hyun JW, Lee KW, Shin T, Jeon YJ, Jee Y.

Toxicol In Vitro. 2011, 25(8), 1789-1795.

Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-κB, Akt, and p38 MAPK.
Kim AR, Lee MS, Shin TS, Hua H, Jang BC, Choi JS, Byun DS, Utsuki T, Ingram D, Kim HR.

Food Chem Toxicol. 2010, 48(6), 1682-1687.

Ecklonia cava extracts inhibit lipopolysaccharide induced inflammatory responses in human endothelial cells
Kim TH, Bae JS.

Food Chem Toxicol. 2010, 48(10), 2925-2933.

Effect of phloroglucinol on oxidative stress and inflammation.
Kim MM, Kim SK.

J Agric Food Chem. 2009, 57(9), 3483-3489.

Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties.
Kim AR, Shin TS, Lee MS, Park JY, Park KE, Yoon NY, Kim JS, Choi JS, Jang BC, Byun DS, Park NK, Kim HR.

J Agric Food Chem. 2009, 57(10), 4439-4446.

Inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on COX-2 and iNOS in microglial cells.
Jung WK, Heo SJ, Jeon YJ, Lee CM, Park YM, Byun HG, Choi YH, Park SG, Choi IW.

Food Chem Toxicol. 2009, 47(2), 410-407.

Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-kB pathways.
Jung WK, Ahn YW, Lee SH, Choi YH, Kim SK, Yea SS, Choi I, Park AG, Seo SK, Lee SW, Choi IW.

Chem Biol Interact . 2009, 179(2-3), 192-201.

Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: implication for chronic articular disease.
Ryu B, Li Y, Qian ZJ, Kim MM, Kim SK.

Arch Pharm Res. 2006, 29(2), 165-171.

An antioxidative and antiinflammatory agent for potential treatment of osteoarthritis from Ecklonia cava.
Shin HC, Hwang HJ, Kang KJ, Lee BH.

Lab Anim Res. 2005, 21(4), 385-389.

Suppression of iNOS expression by phlorotannins in chronic exposure of skin to UVB radiation.
Hwang H, Chen T, Stoner GD, Lee KB, Yoo YC, Shin HC.

J Appl Phycol. 2003, 15(1), 61-66.

Inhibitory effects of brown algal phlorotannins on secretory phospholipase A2s, lipoxygenases and cyclooxygenases.
Shibata T, Nagayama K, Tanaka R, Yamaguchi K, Nakamura T.

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