Topical Applicaion of Dieckol Ameliorates Atopic Dermatitis in NC/Nga Mice by Suppressing Thymic Stromal Lymphopoietin Production.
Yang G, Oh JW, Lee HE, Lee BH, Lim KM, Lee JY.

Protective effects of the seaweed phlorotannin polyphenolic compound dieckol on gentamicin-induced damage in auditory hair cells.
Chang MY, Byon HS, Shin HC, Han SY, Kim JY, Byun JY, Lee JD, Park MK.

Effect of Ecklonia Cava Polyphenol Extract in House Ear Institute-Organ of Corti 1 Cells Against Cisplatin Ototoxicity: A Preliminary Study.
Düzenli U, Olgun Y, Aktaş S, Pamukoğlu A, Altun Z.

Protective effect of a purified polyphenolic extract from Ecklonia cava against noise-induced hearing loss: Prevention of temporary threshold shift.
Chang MY, Han SY, Shin HC, Byun JY, Rah YC, Park MK.

Enhancement of Human Hair Growth Using Ecklonia cava Polyphenols.
Shin H, Cho AR, Kim DY, Munkhbayer A, Choi SJ, Jang S, Kim SH, Shin HC, Kwon O.

6,6'-Bieckol suppresses inflammatory responses by down-regulating nuclear factor-κB activation via Akt, JNK, and p38 MAPK in LPS-stimulated microglial cells.
Kim AR, Lee B, Joung EJ, Gwon WG, Utsuki T, Kim NG, Kim HR.

Protective effects of dieckol on N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Sadeeshkumar V, Duraikannu A, Ravichandran S, Fredrick WS, Sivaperumal R, Kodisundaram P.

Protective Effect of Brown Alga Phlorotannins against Hyper-inflammatory Responses in Lipopolysaccharide-Induced Sepsis Models.
Yang YI, Woo JH, Seo YJ, Lee KT, Lim Y, Choi JH.

MicroRNA134 Mediated Upregulation of JNK and Downregulation of NFkB Signalings Are Critically Involved in Dieckol Induced Antihepatic Fibrosis.
Lee SY, Lee J, Lee H, Kim B, Lew J, Baek N, Kim SH.

Protective effects of Ecklonia stolonifera extract on ethanol induced fatty liver in rats.
Bang, CY, Byun JH, Choi HK, Choi JS, Choung SY.

Dioxinodehydroeckol Enhances the Differentiation of Osteoblasts by Regulating the Expression of Phospho-Smad1/5/8.
Ahn BN, Karadeniz F, Kong CS, Nam KH, Jang MS, Seo Y, Kim HS.

Enrichment of enzymatically mineralized gellan gum hydrogels with phlorotannin-rich Ecklonia cava extract Seanol® to endow antibacterial properties and promote mineralization
Douglas TE, Dokupil A, Reczyńska K, Brackman G, Krok-Borkowicz M, Keppler JK, Božič M, Van Der Voort P, Pietryga K, Samal SK, Balcaen L, van den Bulcke J, Van Acker J, Vanhaecke F, Schwarz K, Coenye T, Pamuła E.

Antimicrobial, Antioxidant, and Anticancer Activities of Biosynthesized Silver Nanoparticles Using Marine Algae Ecklonia cava.
Venkatesan J, Kim SW, Shim MS.

A prebiotic role of Ecklonia cava improves the mortality of Edwardsiellatarda-infected zebrafish models via regulating the growth of lactic acid bacteria and pathogen bacteria.
Lee W, Oh JY, Kim EA, Kang N, Kim KN, Ahn G, Jeon YJ.

A prebiotic effect of Ecklonia cava on the growth and mortality of olive flounder infected with pathogenic bacteria.
Lee W, Ahn G, Oh JY, Kim SM, Kang N, Kim EA, Kim KN, Jeong JB, Jeon YJ.

The cytoprotective effects of ethanol extract of Ecklonia cava against oxidative stress are associated with upregulation of Nrf2-mediated HO-1 and NQO-1 expression through activation of the MAPK pathway.
Choi YH.

Brown alga Ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress and inflammation by activation of AMPK and SIRT1 in high fat diet-induced obese mice.
Eo H, Jeon YJ, Lee M, Lim Y.

Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways.
Cui Y, Park JY, Wu J, Lee JH, Yang YS, Kang MS, Jung SC, Park JM, Yoo ES, Kim SH, Ahn Jo S, Suk K, Eun SY.

Multifunctional Activity of Polyphenolic Compounds Associated with a Potential for Alzheimer's Disease Therapy from Ecklonia cava.
Choi BW, Lee HS, Shin HC, Lee BH.

Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors.
Kwak JH, Yang Z, Yoon B, He Y, Uhm S, Shin HC, Lee BH, Yoo YC, Lee KB, Han SY, Kim JS.

Acetyl- and butyryl-cholinesterase inhibitory activities of the edible brown alga Eisenia bicyclis. Arch Pharm Res.
Choi JS, Haulader S, Karki S, Jung HJ, Kim HR, Jung HA.

Dieckol, a major phlorotannin in Ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell cycle arrest and AMPKa activation.
Choi HS, Jeon HJ, Lee OH, Lee BY.

Protective effect of fucosterol isolated from the edible brown algae, Ecklonia stolonifera and Eisenia bicyclis, on tert-butyl hydroperoxide- and tacrine-induced HepG2 cell injury.
Choi JS, Han YR, Byeon JS, Choung SY, Sohn HS, Jung HA.

Evaluation of Effective MMP Inhibitors from Eight Different Brown Algae in Human Fibrosarcoma HT1080 Cells.
Bae MJ, Karadeniz F, Ahn BN, Kong CS.

First Evidence that Ecklonia cava-Derived Dieckol Attenuates MCF-7 Human Breast Carcinoma Cell Migration.
Kim EK, Tang Y, Kim YS, Hwang JW, Choi EJ, Lee JH, Lee SH, Jeon YJ, Park PJ.

A sulfated polysaccharide of Ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosis.
Ahn G, Lee W, Kim KN, Lee JH, Heo SJ, Kang N, Lee SH, Ahn CB, Jeon YJ.

Dieckol as a novel anti-proliferative and anti-angiogenic agent and computational anti-angiogenic activity evaluation.
Li YX, Li Y, Je JY, Kim SK.

Dieckol, isolated from the edible brown algae Ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth.
Ahn JH, Yang YI, Lee KT, Choi JH.

Phloroglucinol suppresses metastatic ability of breast cancer cells by inhibition of epithelial-mesenchymal cell transition.
Kim RK, Suh Y, Yoo KC, Cui YH, Hwang E, Kim HJ, Kang JS, Kim MJ, Lee YY, Lee SJ.

Dieckol, a phlorotannin of Ecklonia cava, suppresses IgE-mediated mast cell activation and passive cutaneous anaphylactic reaction.
Ahn G, Amagai Y, Matsuda A, Kang SM, Lee W, Jung K, Oida K, Jang H, Ishizaka S, Matsuda K, Jeon YJ, Jee Y, Matsuda H, Tanaka A.

Dieckol, a major phlorotannin in Ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell cycle arrest and AMPKa activation.
Choi HS, Jeon HJ, Lee OH, Lee BY.

Ecklonia cava Polyphenol Has a Protective Effect against Ethanol-Induced Liver Injury in a Cyclic AMP-Dependent Manner.
Yamashita H, Goto M, Matsui-Yuasa I, Kojima-Yuasa A.

Efficacy and safety of a dieckol-rich extract (AG-dieckol) of brown algae, Ecklonia cava, in pre-diabetic individuals: a double-blind, randomized, placebo-controlled clinical trial.
Lee SH, Jeon YJ.

Polyphenol-Rich Fraction of Ecklonia cava Improves Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice.
Park EY, Choi H, Yoon JY, Lee IY, Seo Y, Moon HS, Hwang JH, Jun HS.

Phlorofucofuroeckol A isolated from Ecklonia cava alleviates postprandial hyperglycemia in diabetic mice.
You HN, Lee HA, Park MH, Lee JH, Han JS.

Seapolynol Extracted from Ecklonia cava Inhibits Adipocyte Differentiation in Vitro and Decreases Fat Accumulation in Vivo.
Jeon HJ, Choi HS, Lee YJ, Hwang JH, Lee OH, Seo MJ, Kim KJ, Lee BY.

Seapolynol and Dieckol Improve Insulin Sensitivity through the Regulation of the PI3K Pathway in C57BL/KsJ-db/db Mice.
Jeon HJ, Yoon KY, Koh EJ, Choi J, Kim KJ, Choi HS, Lee BY.

6,6'-Bieckol inhibits adipocyte differentiation through downregulation of adipogenesis and lipogenesis in 3T3-L1 cells.
Kwon TH, Wu YX, Kim JS, Woo JH, Park KT, Kwon OJ, Seo HJ, Kim T, Park NH.