2014-2013

Gynecol Oncol. 2014, 136(2), 355-364.

Brown algae phlorotannins enhance the tumoricidal effect of cisplatin and ameliorate cisplatin nephrotoxicity.
Yang YI, Ahn JH, Choi YS, Choi JH.

J Am Coll Cardiol. 2014, 63(12_S), A873.

Cardioprotective effects of Eckonia cava polyphenol against doxorubicin-induced cardiotoxicity in an amimal rat model with the evidence of electron microscopic finding.
Ahn, HS, Jeon, HK, Kim GH, Chung, WB, Cho, JS, Kim MJ, Cho, EJ, Jung, HO, Youn, HJ.

Carbohydr Polym. 2014, 99, 101-109.

Structure, enzymatic transformation and anticancer activity of branched high molecular weight laminaran from brown alga Eisenia bicyclis.
Menshova RV, Ermakova SP, Anastyuk SD, Isakov VV, Dubrovskaya YV, Kusaykin MI, Um BH, Zvyagintseva TN.

Oral Dis. 2014, 20(8), 827-832.

Eckols reduce dental pulp inflammation through the ERK1/2 pathway independent of COX-2 inhibition.
Paudel U, Lee YH, Kwon TH, Park NH, Yun BS, Hwang PH, Yi HK.

Botanical Sciences. 2014, 92(3), 425-431.

Antibacterial Activity of the Phlorotannins Dieckol and Phlorofucofuroeckol-A from Ecklonia cava against Propipnibacterium Acnes.
Choi JS, Lee K, Lee BB, Kim YC, Kim YD, Hong YK, Cho KK, Choi IS.

Int J Radiat Biol. 2014, 90(10), 928-935.

Phloroglucinol inhibits ultraviolet B radiation-induced oxidative stress in the mouse skin.
Piao MJ, Ahn MJ, Kang KA, Kim KC, Zheng J, Yao CW, Cha JW, Hyun CL, Kang HK, Lee NH, Hyun JW.

Int J Radiat Biol. 2014, 90(10), 928-935.

Phloroglucinol inhibits ultraviolet B radiation-induced oxidative stress in the mouse skin. br> Piao MJ, Ahn MJ, Kang KA, Kim KC, Zheng J, Yao CW, Cha JW, Hyun CL, Kang HK, Lee NH, Hyun JW.

Acta Histochem. 2014, 116(5), 669-674.

Antioxidant marine algae phlorotannins and radioprotection: A review of experimental evidence.
Shin T, Ahn M, Hyun JW, Kim SH, Moon C.

J Am Coll Cardiol. 2014, 63(12S), A873.

Cardioprotective effects of Eckonia cava polyphenol against doxorubicin-induced cardiotoxicity in an amimal rat model with the evidence of electron microscopic finding.
Ahn, HS, Jeon, HK, Kim GH, Chung, WB, Cho, JS, Kim MJ, Cho, EJ, Jung, HO, Youn, HJ.

Biomed Res Int. 2014, 2014, 121396.

Alga Ecklonia bicyclis, Tribulus terrestris, and glucosamine oligosaccharide improve erectile function, sexual quality of life, and ejaculation function in patients with moderate mild-moderate erectile dysfunction: a prospective, randomized, placebo-controlled, single-blinded study.
Sansalone S, Leonardi R, Antonini G, Vitarelli A, Vespasiani G, Basic D, Morgia G, Cimino S, Russo GI.

Int Immunopharmacol. 2014, 23, 460-468.

8,8'-Bieckol, isolated from edible brown algae, exerts its anti-inflammatory effects through inhibition of NF-κB signaling and ROS production in LPS-stimulated macrophages.
Yang YI, Jung SH, Lee KT, Choi JH.

Algae 2014, 29(2), 165-174.

Polyphenol-rich fraction from Ecklonia cava (a brown alga) processing by-product reduces LPS- induced inflammation in vitro and in vivo in a zebrafish model.
Kim SY, Kim EA, Kang MC, Lee, JH, Yang HW, Lee JS, Lim TI, Jeon YJ.

Int Immunopharmacol 2014, 22(1), 51-58.

Hemeoxygenase 1 partly mediates the anti-inflammatory effect of dieckol in lipopolysaccharide stimulated murine macrophages.
Yayeh T, Im EJ, Kwon TH, Roh SS, Kim S, Hong SB, Cho JY, Park NH, Rhee MH.

Appl Biochem Biotechnol. 2014, 173(4), 957-967.

Suppression of NF-κB by Dieckol Extracted from Ecklonia cava Negatively Regulates LPS Induction of Inducible Nitric Oxide Synthase Gene.
Choi HJ, Park JH, Lee BH, Chee HY, Lee KB, Oh SM.

Chem Commun (Camb). 2014, 50(86), 13045-13048.

Synthesis of rhodamine-labelled dieckol: its unique intracellular localization and potent anti-inflammatory activity.
Kwak JH, He Y, Yoon B, Koo S, Yang Z, Kang EJ, Lee BH, Han SY, Yoo YC, Lee KB, Kim JS.

Int J Biol Macromol. 2014, 67, 303-311.

Water soluble sulfated-fucans with immune-enhancing properties from Ecklonia cava.
Cao RA, Lee Y, You S.

Asian Pac J Trop Biomed. 2014, 4(7), 529-537.

Jeju seaweeds suppress lipopolysaccharide-stimulated proinflammatory response in RAW 264.7 murine macrophages.
Yang EJ, Moon JY, Kim SS, Yang KW, Lee WJ, Lee NH, Hyun CG.

Fish Aquat Sci. 2014, 17(1), 19-25.

Sleep-Promoting Effect of Ecklonia cava: Ethanol Extract Promotes Non-rapid Eye Movement Sleep in C57BL/6N Mice.
Yoon M, Kim JS, Jo J, Han D, Cho S.

Molecules. 2014, 19(6), 7669-7678.

The Edible Brown Seaweed Ecklonia cava Reduces Hypersensitivity in Postoperative and Neuropathic Pain Models in Rats.
Kim JG, Lim DW, Cho S, Han D, Kim YT.

Kor J Herbology 2014, 29(6), 103-109.

Effect of Ecklonia cava Extracts Supplementation on cognitive ability in mice.
Oh JK, Song KJ, Ji MY, Yoon JH.

Psychopharmacology (Berl). 2014, 231(14), 2825-2837.

Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor.
Cho S, Yoon M, Pae AN, Jin YH, Cho NC, Takata Y, Urade Y, Kim S, Kim JS, Yang H, Kim J, Kim J, Han JK, Shimizu M, Huang ZL.

Appl Biochem Biotechnol. 2014, 174(2), 632-643.

6,6'-Bieckol Isolated from Ecklonia cava Protects Oxidative Stress Through Inhibiting Expression of ROS and Proinflammatory Enzymes in High-Glucose-Induced Human Umbilical Vein Endothelial Cells.
Park MH, Heo SJ, Park PJ, Moon SH, Sung SH, Jeon BT, Lee SH.

Prev Nutr Food Sci. 2014, 19(3), 170-177.

Effect of Baechu Kimchi Added Ecklonia cava Extracts on High Glucose-induced Oxidative Stress in Human Umbilical Vein Endothelial Cells.
Lee HA, Song YO, Jang MS, Han JS.

Fitoterapia. 2014, 92, 260-269.

Phlorotannins isolated from the edible brown alga Ecklonia stolonifera exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBPα and PPARγ.
Jung HA, Jung HJ, Jeong HY, Kwon HJ, Ali MY, Choi JS.

Biosci Biotechnol Biochem. 2014, 78(5), 832-838.

A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation.
Mori T, Hidaka M, Ikuji H, Yoshizawa I, Toyohara H, Okuda T, Uchida C, Asano T, Yotsu-Yamashita M, Uchida T.

Environ Toxicol Pharmacol. 2014, 38(2), 607-615.

Octaphlorethol A isolated from Ishige foliacea prevents and protects against high glucose-induced oxidative damage in vitro and in vivo.
Kang MC, Kim KN, Chaminda Lakmal HH, Kim EA, Wijesinghe WA, Yang X, Heo SJ, Jeon YJ.

J Pharm Pharmacol. 2014, 66(8), 1180-1188.

Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes.
Jung HA, Kim JI, Choung SY, Choi JS.

Arch Pharm Res. 2014, 37(6), 713-720.

Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes.
Jung HA, Jung HJ, Jeong HY, Kwon HJ, Kim MS, Choi JS.

J Microbiol Biotechnol. 2014, 24(4), 465-474.

Inhibitory effects of brown algae extracts on histamine production in mackerel muscle via inhibition of growth and histidine decarboxylase activity of Morganella morganii.
Kim DH, Kim KB, Cho JY, Ahn DH.

Biosci Biotechnol Biochem. 2014, 78(7), 1151-1158.

Anti-HIV-1 activity of phlorotannin derivative 8,4‴-dieckol from Korean brown alga Ecklonia cava.
Karadeniz F, Kang KH, Park JW, Park SJ, Kim SK.

Appl Microbiol Biotechnol. 2014, 98(23), 9795-9804.

The mechanism of antibacterial activity of phlorofucofuroeckol-A against methicillin-resistant Staphylococcus aureus.
Eom SH, Lee DS, Jung YJ, Park JH, Choi JI, Yim MJ, Jeon JM, Kim HW, Son KT, Je JY, Lee MS, Kim YM.

Appl Biochem Biotechnol. 2014, 174(2), 632-643.

6,6'-Bieckol Isolated from Ecklonia cava Protects Oxidative Stress Through Inhibiting Expression of ROS and Proinflammatory Enzymes in High-Glucose-Induced Human Umbilical Vein Endothelial Cells.
Park MH, Heo SJ, Park PJ, Moon SH, Sung SH, Jeon BT, Lee SH.

Int Immunopharmacol 2014, 22(1), 51-58.

Hemeoxygenase 1 partly mediates the anti-inflammatory effect of dieckol in lipopolysaccharide stimulated murine macrophages.
Yayeh T, Im EJ, Kwon TH, Roh SS, Kim S, Hong SB, Cho JY, Park NH, Rhee MH.

Molecules. 2014, 19(10), 15638-15652.

Eckol Enhances Heme Oxygenase-1 Expression through Activation of Nrf2/JNK Pathway in HepG2 Cells.
Jun YJ, Lee M, Shin T, Yoon N, Kim JH, Kim HR.

J Cell Biochem. 2014, 115(8), 1403-1411.

Cytoprotective effect of eckol against oxidative stress-induced mitochondrial dysfunction: Involvement of the FoxO3a/AMPK pathway.
Kim AD, Kang KA, Piao MJ, Kim KC, Zheng J, Yao CW, Cha JW, Hyun CL, Kang HK, Lee NH, Hyun JW.

Biomol Ther (Seoul). 2014, 22(4), 301-307.

Fucodiphlorethol G Purified from Ecklonia cava Suppresses Ultraviolet B Radiation-Induced Oxidative Stress and Cellular Damage.
Kim KC, Piao MJ, Zheng J, Yao CW, Cha JW, Kumara MH, Han X, Kang HK, Lee NH, Hyun JW.

Mar Drugs. 2014, 12(11), 5357-5371.

Triphlorethol-A from Ecklonia cava Up-Regulates the Oxidant Sensitive 8-Oxoguanine DNA Glycosylase 1.
Kim KC, Lee IK, Kang KA, Piao MJ, Ryu MJ, Kim JM, Lee NH, Hyun JW.

Algagl Research. 2013, 2(1), 51-58.

Water-soluble polysaccharides from the brown alga Eisenia bicyclis: Structural characteristics and antitumor activity.
Ermakova S, Men'Shova R, Vishchuk O, Kim SM, Um BH, Isakov V, Zvyaginteseva T.

J Nat Med. 2013, 67(3), 519-527.

Dieckol, isolated from Ecklonia stolonifera, induces apoptosis in human hepatocellular carcinoma Hep3B cells.
Yoon JS, Kasin Yadunandam A, Kim SJ, Woo HC, Kim HR, Kim GD.

J Histochem Cytochem. 2013, 61(1), 63-74.

Phloroglucinol protects small intestines of mice from ionizing radiation by regulating apoptosis-related molecules: a comparative immunohistochemical study.
Ha D, Bing SJ, Cho J, Ahn G, Kim DS, Al-Amin M, Park SJ, Jee Y.

Int J Biol Macromol. 2013, 52, 260-266.

Radio-protective effect of polysaccharides isolated from Lactobacillus brevis-fermented Ecklonia cava.
Lee W, Ahn G, Lee BJ, Wijesinghe WA, Kim D, Yang H, Kim YM, Park SJ, Jee Y, Jeon YJ.

European J Heart Failure. 2013, 12(1), S101.

Cardioprotective effects of seapolynol (polyphenol purified from ecklonia cava) against adriamycin-induced cardiomyopathy in an animal rat model.
Jeon HK, Lee DH, Youn HJ, Shin HC.

Carbohydr Polym. 2013, 92(1), 84-89.

Anti-inflammatory effect of fucoidan extracted from Ecklonia cava in zebrafish model.
Lee SH, Ko CI, Jee Y, Jeong Y, Kim M, Kim JS, Jeon YJ.

Food Chem Toxicol. 2013, 59, 199-206.

Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages.
Jung HA, Jin SE, Ahn BR, Lee CM, Choi JS.

Environ Toxicol Pharmacol. 2013, 35(3), 395-401.

Protective effect of phlorotannins from Eisenia bicyclis against lipopolysaccharide-stimulated inflammation in HepG2 cells.
Kang YM, Eom SH, Kim YM.

Inflammation. 2013, 36(2), 259-271.

Phlorofucofuroeckol A Suppresses Expression of Inducible Nitric Oxide Synthase, Cyclooxygenase-2, and Pro-inflammatory Cytokines via Inhibition of Nuclear Factor-κB, c-Jun NH(2)-Terminal Kinases, and Akt in Microglial Cells.
Kim AR, Lee MS, Choi JW, Utsuki T, Kim JI, Jang BC, Kim HR.

Biochim Biophys Acta. 2013, 1830(3), 2820-2829.

The JNK/NFκB pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from Ecklonia cava.
Ahn G, Bing SJ, Kang SM, Lee WW, Lee SH, Matsuda H, Tanaka A, Cho IH, Jeon YJ, Jee Y.

Food Research Internatioanl. 2013, 54, 1250-1254.

Acetylcholinesterase inhibitory activity of phlorotannins isolated form the brown alga, Ecklonia maxima (Osbeck) Papenfuss.
Kannan, R.R.R., Aderogba, M.A., Ndhlala, A.R., Stirk, W.A., Van Staden, J.

Inflammation. 2013, 36(2), 259-271.

Phlorofucofuroeckol A Suppresses Expression of Inducible Nitric Oxide Synthase, Cyclooxygenase-2, and Pro-inflammatory Cytokines via Inhibition of Nuclear Factor-κB, c-Jun NH(2)-Terminal Kinases, and Akt in Microglial Cells.
Kim AR, Lee MS, Choi JW, Utsuki T, Kim JI, Jang BC, Kim HR.

Neurotoxicology. 2013, 34, 16-24.

Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity.
Kang IJ, Jang BG, In S, Choi B, Kim M, Kim MJ.

Environ Toxicol Pharmacol. 2013, 36(3), 1217-1226.

Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model.
Kang MC, Kim KN, Kang SM, Yang X, Kim EA, Song CB, Nah JW, Jang MK, Lee JS, Jung WK, Jeon YJ.

Food Chem Toxicol. 2013, 53, 294-298.

Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model.
Kang MC, Wijesinghe WA, Lee SH, Kang SM, Ko SC, Yang X, Kang N, Jeon BT, Kim J, Lee DH, Jeon YJ.

Environ Toxicol Pharmacol. 2013, 36(3), 1253-1260

Dieckol, a phlorotannin isolated from a brown seaweed, Ecklonia cava, inhibits adipogenesis through AMP-activated protein kinase (AMPK) activation in 3T3-L1 preadipocytes.
Ko SC, Lee M, Lee JH, Lee SH, Lim Y, Jeon YJ.

Prev Nutr Food Sci. 2013, 18(3), 163-168.

Alleviating Effects of Baechu Kimchi Added Ecklonia cava on Postprandial Hyperglycemia in Diabetic Mice.
Lee HA, Song YO, Jang MS, Han JS.

Chem Biol Interact. 2013, 206(1), 55-62.

Kinetics and molecular docking studies of an anti-diabetic complication inhibitor fucosterol from edible brown algae Eisenia bicyclis and Ecklonia stolonifera.
Jung HA, Islam MN, Lee CM, Oh SH, Lee S, Jung JH, Choi JS.

Environ Toxicol Pharmacol. 2013, 35(3), 395-401.

Protective effect of phlorotannins from Eisenia bicyclis against lipopolysaccharide-stimulated inflammation in HepG2 cells.
Kang YM, Eom SH, Kim YM.

J Agric Food Chem. 2013, 61(36), 8541-8547.

Evaluation of Inhibitory Effect of Phlorotannins from Ecklonia cava on Triglyceride Accumulation in Adipocyte.
Kim H, Kong CS, Lee JI, Kim H, Baek S, Seo Y.

Bioorg Med Chem. 2013, 21(13), 3730-3737.

Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava.
Park JY, Kim JH, Kwon JM, Kwon HJ, Jeong HJ, Kim YM, Kim D, Lee WS, Ryu YB.

Appl Biochem Biotechnol. 2013, 171(3), 569-582.

Application of yeast Candida utilis to ferment Eisenia bicyclis for enhanced antibacterial effect.
Eom SH, Lee DS, Kang YM, Son KT, Jeon YJ, Kim YM.

PLoS One. 2013, 8(8), e72203.

Antifungal activity of phlorotannins against dermatophytes and yeasts: approaches to the mechanism of action and influence on Candida albicans virulence factor.
Lopes G, Pinto E, Andrade PB, Valentão P.

Bioorg Med Chem. 2013, 21(15), 4706-4713.

In vitro antiviral activity of phlorotannins isolated from Ecklonia cava against porcine epidemic diarrhea coronavirus infection and hemagglutination.
Kwon HJ, Ryu YB, Kim YM, Song N, Kim CY, Rho MC, Jeong JH, Cho KO, Lee WS, Park SJ.

Phytother Res. 2013, 27(8), 1260-1264.

In Vitro Antibacterial Activity and Synergistic Antibiotic Effects of Phlorotannins Isolated from Eisenia bicyclis Against Methicillin-Resistant Staphylococcus aureus.
Eom SH, Kim DH, Lee SH, Yoon NY, Kim JH, Kim TH, Chung YH, Kim SB, Kim YM, Kim HW, Lee MS, Kim YM.

Free Radic Res. 2013, 47(6-7), 526-534.

Cytoprotective effect of dieckol on human endothelial progenitor cells (hEPCs) from oxidative stress-induced apoptosis.
Lee SH, Kim JY, Yoo SY, Kwon SM.

J Food Sci. 2013, 78(5), C679-C684.

Antioxidant activity of various solvent fractions from edible brown alga, Eisenia bicyclis and its active compounds.
Kwon TH, Kim TW, Kim CG, Park NH.

Food Chem. 2013, 141(2), 1412-1415.

Potential antiradical and alpha-glucosidase inhibitors from Ecklonia maxima (Osbeck) Papenfuss.
Rengasamy KR, Aderogba MA, Amoo SO, Stirk WA, Van Staden J.

Mar Drugs. 2013, 11(1), 165-183.

Isolation and structural determination of two novel phlorotannins from the brown alga Ecklonia kurome Okamura, and their radical scavenging activities.
Yotsu-Yamashita M, Kondo S, Segawa S, Lin YC, Toyohara H, Ito H, Konoki K, Cho Y, Uchida T.

Food Chem. 2013, 138(2-3), 950-955.

Protective effect of marine algae phlorotannins against AAPH-induced oxidative stress in zebrafish embryo.
Kang MC, Cha SH, Wijesinghe WA, Kang SM, Lee SH, Kim EA, Song CB, Jeon YJ.

Clin Exp Dermatol. 2013, 38(8), 904-910.

Ecklonia cava promotes hair growth.
Bak SS, Ahn BN, Kim JA, Shin SH, Kim JC, Kim MK, Sung YK, Kim SK.

Free Radicals and Antioxidants. 2013, 3, S1-S10.

Isolation, identification and radical scavenging activity of phlorotannin derivatives from brown algae, Ecklonia maxima: An experimental and theoretical study.
Mwangi H, Van Der Westhuizen J, Marnewick J, Mabusela W, Kabanda M, Ebenso E.

Mar Biotechnol (NY). 2013, 15(4), 487-498.

Investigation of Proteomic Profiles of Lamina of Ecklonia kurome (Laminariales): Homology-Based Cross-Species Protein Identification and Analysis of the Post-translational Processing of Vanadium-Dependent Bromoperoxidases Using MALDI-TOF/TOF.
Nagai K, Morimoto K, Ikegami H, Kimura H, Yotsukura N.

The Center for the Science of SEANOL®

learn more