2012-2011

Mol Cells. 2012, 33(2), 141-149.

Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling.
Park SJ, Jeon YJ.

PLoS One. 2012, 7(3), e33618.

Phloroglucinol Inhibits the Bioactivities of Endothelial Progenitor Cells and Suppresses Tumor Angiogenesis in LLC-Tumor-Bearing Mice.
Kwon YH, Jung SY, Kim JW, Lee SH, Lee JH, Lee BY, Kwon SM.

European Heart J. 2012, 33(Supl 1), 328.

Cardioprotective effects of seapolynol (polyphenol purified from ecklonia cava) against adriamycin-induced cardiomyopathy in an animal rat model.
Jeon HK, Lee DH, Shin HC, Youn HJ, Kim KT.

Food Chem Toxicol. 2012, 50(6), 2188-2195.

Phloroglucinol (PG) purified from Ecklonia cava attenuates radiation-induced apoptosis in blood lymphocytes and splenocytes. Park SJ, Ahn G, Lee NH, Park JW, Jeon YJ, Jee Y.
Int J Radiat Biol. 2010, 86(10), 848-859.

BMC Surg. 2012, 12 (Suppl 1), S22.

Observational study: daily treatment with a new compound ""tradamixina"" plus serenoa repens for two months improved the lower urinary tract symptoms.
Iacono F, Prezioso D, Illiano E, Ruffo A, Romeo G, Amato B.

BMC Surg. 2012, 12 (Suppl 1), S23.

Sexual asthenia: Tradamixina versus Tadalafil 5 mg daily.
Iacono F, Prezioso D, Illiano E, Romeo G, Ruffo A, Amato B.

Asian Pac J Trop Med. 2012, 5(5), 374-379.

Insulinotrophic and hypolipidemic effects of Ecklonia cava in streptozotocin-induced diabetic mice.
Kim MJ, Kim HK.

J Cell Biochem. 2012, 113(9), 2877-2883.

Antithrombotic and profibrinolytic activities of eckol and dieckol.
Kim TH, Ku SK, Bae JS.

J Med Food. 2012, 15(11), 1038-1044.

Effects of Ecklonia cava Polyphenol in Individuals with Hypercholesterolemia: A Pilot Study.
Lee DH, Park MY, Shim BJ, Youn HJ, Hwang HJ, Shin HC, Jeon HK.

Int Immunopharmacol. 2012, 12(3), 510-517.

6,6'-Bieckol, isolated from marine alga Ecklonia cava, suppressed LPS-induced nitric oxide and PGE(2) production and inflammatory cytokine expression in macrophages: The inhibition of NFκB.
Yang YI, Shin HC, Kim SH, Park WY, Lee KT, Choi JH.

J Agric Food Chem. 2012, 60(36), 9120-9129.

Anti-inflammatory activities of an ethanol extract of Ecklonia stolonifera in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
Lee MS, Kwon MS, Choi JW, Shin T, No HK, Choi JS, Byun DS, Kim JI, Kim HR.

PhD Thesis, 2012, Department of Physiology, Graduate School, Jeju Natioanl University.

Neuroprotective Mechanisms of Antioxidant Dieckol against Microglia-mediated Neurotoxicity and Mitochondrial-dependent Neuronal Cell Death.
Cui YJ.

Arch Pharm Res. 2012, 35(11), 1989-1998.

Neuroprotective effect of edible brown alga Eisenia bicyclis on amyloid beta peptide-induced toxicity in PC12 cells.
Ahn BR, Moon HE, Kim HR, Jung HA, Choi JS.

Biosci Biotechnol Biochem. 2012, 76(1), 163-168.

Depressive Effects on the Central Nervous System and Underlying Mechanism of the Enzymatic Extract and Its Phlorotannin-Rich Fraction from Ecklonia cava Edible Brown Seaweed.
Cho S, Han D, Kim SB, Yoon M, Yang H, Jin YH, Jo J, Yong H, Lee SH, Jeon YJ, Shimizu M.

Anat Cell Biol. 2012, 45(2), 103-113.

Protective efficacy of an Ecklonia cava extract used to treat transient focal ischemia of the rat brain.
Kim JH, Lee NS, Jeong YG, Lee JH, Kim EJ, Han SY.

Int J Mol Sci. 2012, 13(5), 6407-6423.

Effect of Dieckol, a Component of Ecklonia cava, on the Promotion of Hair Growth.
Kang JI, Kim SC, Kim MK, Boo HJ, Jeon YJ, Koh YS, Yoo ES, Kang SM, Kang HK.

Exp Dermatol. 2012, 21(6), 471-473.

Dioxinodehydroeckol inhibits melanin synthesis through PI3K/Akt signalling pathway in α-melanocyte-stimulating hormone-treated B16F10 cells.
Lee MS, Yoon HD, Kim JI, Choi JS, Byun DS, Kim HR.

Bioorg Med Chem. 2012, 20(1), 311-316.

Molecular docking studies of a phlorotannin, dieckol isolated from Ecklonia cava with tyrosinase inhibitory activity.
Kang SM, Heo SJ, Kim KN, Lee SH, Yang HM, Kim AD, Jeon YJ.

Vet Dermatol. 2012, 23(1), 51-56.

Protective effects of phlorotannins against ultraviolet B radiation in zebrafish (Danio rerio).
Cha SH, Ko CI, Kim D, Jeon YJ.

Biosci Biotechnol Biochem. 2012, 76(8), 1445-1451.

Dieckol Isolated from Ecklonia cava Protects against High-Glucose Induced Damage to Rat Insulinoma Cells by Reducing Oxidative Stress and Apoptosis.
Lee SH, Park MH, Kang SM, Ko SC, Kang MC, Cho S, Park PJ, Jeon BT, Kim SK, Han JS, Jeon YJ.

Food Chem Toxicol. 2012, 50(3-4), 575-582.

Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus.
Lee SH, Min KH, Han JS, Lee DH, Park DB, Jung WK, Park PJ, Jeon BT, Kim SK, Jeon YJ.

Asian Pac J Trop Med. 2012, 5(5), 374-379.

Insulinotrophic and hypolipidemic effects of Ecklonia cava in streptozotocin-induced diabetic mice.
Kim MJ, Kim HK.

Evid Based Complement Alternat Med. 2012, 2012, 439294.

Ecklonia cava Inhibits Glucose Absorption and Stimulates Insulin Secretion in Streptozotocin-Induced Diabetic Mice.
Kim HK.

Appl Biochem Biotechnol. 2012, 167, 1973-1985.

Bioactive Compounds Extracted from Ecklonia cava by Using Enzymatic Hydrolysis Protects High Glucose-Induced Damage in INS-1 Pancreatic β-Cells.
Lee SH, Park MH, Park SJ, Kim J, Kim YT, Oh MC, Jeong Y, Kim M, Han JS, Jeon YJ.

Int J Biomed Sci. 2012, 8(1), 64-75.

Effects of Gametophytes of Ecklonia Kurome on the Levels of Glucose and Triacylglycerol in db/db, Prediabetic C57BL/6J and IFN-γ KO Mice.
Dwiranti F, Hiraoka M, Taguchi T, Konishi Y, Tominaga M, Tominaga A.

J Sci Food Agric. 2012, 92(10), 2084-2090.

α-Glucosidase- and α-amylase-inhibitory activities of phlorotannins from Eisenia bicyclis.
Eom SH, Lee SH, Yoon NY, Jung WK, Jeon YJ, Kim SK, Lee MS, Kim YM.

Phytother Res. 2012, 27, 148-151.

Pancreatic Lipase Inhibitory Activity of Phlorotannins Isolated from Eisenia bicyclis.
Eom SH, Lee MS, Lee EW, Kim YM, Kim TH.

Pharm Biol. 2012, 50(3), 393-400.

Antidiabetic effect of polyphenols from brown alga Ecklonia kurome in genetically diabetic KK-A(y) mice.
Xu HL, Kitajima C, Ito H, Miyazaki T, Baba M, Okuyama T, Okada Y.

Food Chem Toxicol. 2012, 50(6), 1986-1991.

Hepatoprotective effects of dieckol-rich phlorotannins from Ecklonia cava, a brown seaweed, against ethanol induced liver damage in BALB/c mice.
Kang MC, Ahn G, Yang X, Kim KN, Kang SM, Lee SH, Ko SC, Ko JY, Kim D, Kim YT, Jee Y, Park SJ, Jeon YJ.

Evid Based Complement Alternat Med. 2012, 2012, 418912.

Polyphenol-Rich Fraction of Brown Alga Ecklonia cava Collected from Gijang, Korea, Reduces Obesity and Glucose Levels in High-Fat Diet-Induced Obese Mice.
Park EY, Kim EH, Kim MH, Seo YW, Lee JI, Jun HS.

Prev Nutr Food Sci. 2012, 17, 1-7.

Anti-hyperlipidemic Effect of Polyphenol Extract (SeapolynolTM) and Dieckol Isolated from Ecklonia cava in in vivo and in vitro Models.
Yeo AR, Lee J, Tae IH, Park SR, Cho YH, Lee BH, Shin HC, Kim SH, Yoo YC.

Phytother Res. 2012, 26(3), 363-368.

Effects of 12-week Oral Supplementation of Ecklonia cava Polyphenols on Anthropometric and Blood Lipid Parameters in Overweight Korean Individuals: A Double-blind Randomized Clinical Trial.
Shin HC, Kim SH, Park Y, Lee BH, Hwang HJ.

J Med Food. 2012, 15(11), 1038-1044.

Effects of Ecklonia cava Polyphenol in Individuals with Hypercholesterolemia: A Pilot Study.
Lee DH, Park MY, Shim BJ, Youn HJ, Hwang HJ, Shin HC, Jeon HK.

PLoS One. 2012, 7(2), e31145.

Can phlorotannins purified extracts constitute a novel pharmacological alternative for microbial infections with associated inflammatory conditions?
Lopes G, Sousa C, Silva LR, Pinto E, Andrade PB, Bernardo J, Mouga T, Valentão P.

Food Chem Toxicol. 2012, 50(9), 3251-3255.

Antimicrobial effect of phlorotannins from marine brown algae.
Eom SH, Kim YM, Kim SK.

Mol Cells. 2012, 33(4), 363-399.

Antioxidant dieckol downregulates the Rac1/ROS signaling pathway and inhibits Wiskott-Aldrich syndrome protein (WASP)-family verprolin-homologous protein 2 (WAVE2)-mediated invasive migration of B16 mouse melanoma cells.
Park SJ, Kim YT, Jeon YJ.

Mar Biotechnol (NY). 2012, 14(4), 383-395.

Edible seaweed, Eisenia bicyclis, protects retinal ganglion cells death caused by oxidative stress.
Kim KA, Kim SM, Kang SW, Jeon SI, Um BH, Jung SH.

Biol Pharm Bull. 2012, 35(6), 873-880.

Eckol inhibits ultraviolet B-induced cell damage in human keratinocytes via a decrease in oxidative stress.
Piao MJ, Lee NH, Chae S, Hyun JW.

Environ Toxicol Pharmacol. 2012, 34(3), 926-934.

Photo-oxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes.
Jang J, Ye BR, Heo SJ, Oh C, Kang DH, Kim JH, Affan A, Yoon KT, Choi YU, Park SC, Han S, Qian ZJ, Jung WK, Choi IW.

Fitoterapia. 2012, 83, 1060-1067.

Cytoprotective effects of phlorofucofuroeckol A isolated from Ecklonia stolonifera against tacrine-treated HepG2 cells.
Lee MS, Kim JI, Utsuki T, Park NG, Kim HR.

Environ Toxicol Pharmacol. 2012, 34(1), 96-105.

Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H(2)O(2)-induced oxidative stress in murine hippocampal HT22 cells.
Kang SM, Cha SH, Ko JY, Kang MC, Kim D, Heo SJ, Kim JS, Heu MS, Kim YT, Jung WK, Jeon YJ.

J Agric Food Chem. 2012, 60(21), 5340-5349.

Isolation and Identification of Phlorotannins from Ecklonia stolonifera with Antioxidant and Hepatoprotective Properties in Tracrine-Treated HepG2 Cells.
Lee MS, Shin TS, Utsuki T, Choi JS, Byun DS, Kim HR.

Biochim Biophys Acta. 2012, 1820, 978-988.

Ecklonia cava polyphenol protects the liver against ethanol-induced injury in rats.
Takahashi M, Satake N, Yamashita H, Tamura A, Sasaki M, Matsui-Yuasa I, Tabuchi M, Akahoshi Y, Terada M, Kojima-Yuasa A.

Evid Based Complement Alternat Med. 2011, 2011, 140462.

Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway.
Zhang C, Li Y, Qian ZJ, Lee SH, Li YX, Kim SK.

J Korean Soc Appl Biol Chem. 2011, 54(3), 376-381.

Dieckol Inhibits 12-O-tetradecanoylphorbol-13-acetate-induced SK-Hep1 Human Hepatoma Cell Motility through Suppression of Matrix Metalloproteinase-9 Activity.
Oh SM, Park CG, Kang JH, Kim EJ, Chee HY, Lee BH, Lee KB.

Toxicol Appl Pharmacol. 2011, 254(1), 32-40.

Eckol suppresses maintenance of stemness and malignancies in glioma stem-like cells.
Hyun KH, Yoon CH, Kim RK, Lim EJ, An S, Park MJ, Hyun JW, Suh Y, Kim MJ, Lee SJ.

J Food Biochem. 2011, 35(2), 357-369.

Cytotoxic Activities of Phlorethol and Fucophlorethol Derivatives Isolated From Laminariaceae Ecklonia cava.
Li Y, Qian ZJ, Kim MM, Kim SK.

Nutr Res Pract. 2011, 5(2), 93-100.

Effect of phlorotannins isolated from Ecklonia cava on angiotensin I-converting enzyme (ACE) inhibitory activity.
Wijesinghe WA, Ko SC, Jeon YJ.

Evid Based Complement Alternat Med. 2011, 2011, 140462.

Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway.
Zhang C, Li Y, Qian ZJ, Lee SH, Li YX, Kim SK.

Mar Biotechnol (NY). 2011, 13, 66-73.

Enzymatic Extract from Ecklonia cava Induces the Activation of Lymphocytes by IL-2 Production Through the Classical NF-kappaB Pathway.
Ahn G, Park E, Lee WW, Hyun JW, Lee KW, Shin T, Jeon YJ, Jee Y.

Toxicol In Vitro. 2011, 25(8), 1789-1795.

Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-κB, Akt, and p38 MAPK.
Kim AR, Lee MS, Shin TS, Hua H, Jang BC, Choi JS, Byun DS, Utsuki T, Ingram D, Kim HR.

Food Chem Toxicol. 2011, 49(9), 2252-2259.

Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death.
Kang IJ, Jeon YE, Yin XF, Nam JS, You SG, Hong MS, Jang BG, Kim MJ.

J Environ Biol. 2011, 32(3), 313-318.

In vitro antibacterial and anti-inflammatory properties of seaweed extracts against acne inducing bacteria, Propionibacterium acnes.
Choi JS, Bae HJ, Kim SJ, Choi IS.

J Dermatol. 2011, 38(4), 354-363.

Screening of marine algae for potential tyrosinase inhibitor: those inhibitors reduced tyrosinase activity and melanin synthesis in zebrafish.
Cha SH, Ko SC, Kim D, Jeon YJ.

Mar Drugs. 2011, 9(12), 2793-2808.

Inhibitory Effects of Ecklonia cava Extract on High Glucose-Induced Hepatic Stellate Cell Activation.
Yokogawa K, Matsui-Yuasa I, Tamura A, Terada M, Kojima-Yuasa A.

Appl Biochem Biotechnol. 2011, 165(5-6), 1296-1307.

Isolation of Phlorotannins from Eisenia bicyclis and Their Hepatoprotective Effect against Oxidative Stress Induced by tert-Butyl Hyperoxide.
Kim SM, Kang K, Jeon JS, Jho EH, Kim CY, Nho CW, Um BH.

Food Chem Toxicol. 2011, 49(9), 2236-2242.

Phloroglucinol (PG) purified from Ecklonia cava attenuates radiation-induced apoptosis in blood lymphocytes and splenocytes.
Park SJ, Ahn G, Lee NH, Park JW, Jeon YJ, Jee Y.

J Agric Food Chem. 2011, 59(12), 6467-6473.

Influenza Virus Neuraminidase Inhibitory Activity of Phlorotannins from the Edible Brown Alga Ecklonia cava.
Ryu YB, Jeong HJ, Yoon SY, Park JY, Kim Y, Park SJ, Rho MC, Kim SJ, Lee WS.

Nutr Res Pract. 2011, 5(6), 495-502.

Evaluation of antioxidant properties of a new compound, pyrogallol-phloroglucinol-6,6'-bieckol isolated from brown algae, Ecklonia cava.
Kang SM, Lee SH, Heo SJ, Kim KN, Jeon YJ.

Biosci Biotechnol Biochem. 2011, 75(8), 1472-1480.

Protein tyrosine phosphatase 1B and α-glucosidase inhibitory Phlorotannins from edible brown algae, Ecklonia stolonifera and Eisenia bicyclis.
Moon HE, Islam N, Ahn BR, Chowdhury SS, Sohn HS, Jung HA, Choi JS.

J Food Sci. 2011. 76(1), C104-C111.

Comparative antioxidant activity of edible Japanese brown seaweeds.
Airanthi MK, Hosokawa M, Miyashita K.

Algae 2011, 26(4):343-350.

Enzyme-assisted extraction of Ecklonia cava fermented with Lactobacillus brevis and isolation of an anti-inflammatory polysaccharide.
Lee WW, Ahn G, Wijesinghe WAJP, Yang X, Ko CI, Kang MC, Lee BJ, Jeon YJ.

Environ Toxicol Pharmacol. 2011, 32(3), 325-335.

Potential pharmacological applications of polyphenolic derivatives from marine brown algae.
Thomas NV, Kim SK.

Food Industry and Nutrition. 2011, 16, 5-11.

Nutraceutical Application of Seanol. Food Industry and Nutrition 16:5-11 (2011)
Shin HC.

Phytochem. Anal. 2011, 22, 322-329.

A preparative method for isolation of fucoxanthin from Eisenia bicyclis by centrifugal partition chromatography.
Kim SA, Shang YF, Um BH.

Sports Science 2011, 29(1), 11-19.

The effect of sports cream on delayed onset muscle soreness.
Oh JK, Yoon JH.

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