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Skin / Hair / Dental

Enhancement of Human Hair Growth Using Ecklonia cava Polyphenols.
Shin H, Cho AR, Kim DY, Munkhbayer A, Choi SJ, Jang S, Kim SH, Shin HC, Kwon O.
Ann Dermatol. 2016, 28(1), 15-21.

Dioxinodehydroeckol protects human keratinocyte cells from UVB-induced apoptosis modulated by related genes Bax/Bcl-2 and caspase pathway.
Ryu B, Ahn BN, Kang KH, Kim YS, Li YX, Kong CS, Kim SK, Kim DG.
J Photochem Photobiol B. 2015, 153, 352-357.

Eckols reduce dental pulp inflammation through the ERK1/2 pathway independent of COX-2 inhibition.
Paudel U, Lee YH, Kwon TH, Park NH, Yun BS, Hwang PH, Yi HK.
Oral Dis. 2014, 20(8), 827-832.

Antibacterial Activity of the Phlorotannins Dieckol and Phlorofucofuroeckol-A from Ecklonia cava against Propipnibacterium Acnes.
Choi JS, Lee K, Lee BB, Kim YC, Kim YD, Hong YK, Cho KK, Choi IS.
Botanical Sciences. 2014, 92(3), 425-431.

Phloroglucinol inhibits ultraviolet B radiation-induced oxidative stress in the mouse skin. br> Piao MJ, Ahn MJ, Kang KA, Kim KC, Zheng J, Yao CW, Cha JW, Hyun CL, Kang HK, Lee NH, Hyun JW.
Int J Radiat Biol. 2014, 90(10), 928-935.

Ecklonia cava promotes hair growth.
Bak SS, Ahn BN, Kim JA, Shin SH, Kim JC, Kim MK, Sung YK, Kim SK.
Clin Exp Dermatol. 2013, 38(8), 904-910.

Effect of Dieckol, a Component of Ecklonia cava, on the Promotion of Hair Growth.
Kang JI, Kim SC, Kim MK, Boo HJ, Jeon YJ, Koh YS, Yoo ES, Kang SM, Kang HK.
Int J Mol Sci. 2012, 13(5), 6407-6423.

Eckol inhibits ultraviolet B-induced cell damage in human keratinocytes via a decrease in oxidative stress.
Piao MJ, Lee NH, Chae S, Hyun JW.
Biol Pharm Bull. 2012, 35(6), 873-880.

Photo-oxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes.
Jang J, Ye BR, Heo SJ, Oh C, Kang DH, Kim JH, Affan A, Yoon KT, Choi YU, Park SC, Han S, Qian ZJ, Jung WK, Choi IW.
Environ Toxicol Pharmacol. 2012, 34(3), 926-934.

Dioxinodehydroeckol inhibits melanin synthesis through PI3K/Akt signalling pathway in α-melanocyte-stimulating hormone-treated B16F10 cells.
Lee MS, Yoon HD, Kim JI, Choi JS, Byun DS, Kim HR.
Exp Dermatol. 2012, 21(6), 471-473.

Molecular docking studies of a phlorotannin, dieckol isolated from Ecklonia cava with tyrosinase inhibitory activity.
Kang SM, Heo SJ, Kim KN, Lee SH, Yang HM, Kim AD, Jeon YJ.
Bioorg Med Chem. 2012, 20(1), 311-316.

Protective effects of phlorotannins against ultraviolet B radiation in zebrafish (Danio rerio).
Cha SH, Ko CI, Kim D, Jeon YJ.
Vet Dermatol. 2012, 23(1), 51-56.

In vitro antibacterial and anti-inflammatory properties of seaweed extracts against acne inducing bacteria, Propionibacterium acnes.
Choi JS, Bae HJ, Kim SJ, Choi IS.
J Environ Biol. 2011, 32(3), 313-318.

Screening of marine algae for potential tyrosinase inhibitor: those inhibitors reduced tyrosinase activity and melanin synthesis in zebrafish.
Cha SH, Ko SC, Kim D, Jeon YJ.
J Dermatol. 2011, 38(4), 354-363.

Antifungal Activities of Dieckol Isolated from the Marine Brown Alga Ecklonia cava against Trichophyton rubrum.
Lee MH, Lee KB, Oh SM, Lee BH, Chee HY.
J Korean Soc Appl Biol Chem. 2010, 53(4), 504-507.

MMT Inhibitory Action of Seanol.
Saeki Y, NishiuraH, Tanaka K.
Fragrance J. 2009, 37, 94-96.

Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation.
Heo SJ, Ko SC, Cha SH, Kang DH, Park HS, Choi YU, Kim D, Jung WK, Jeon YJ.
Toxicol In Vitro. 2009, 23(6), 1123-1130.

Inhibitory efect of phlorotannins isolated from Ecklonia cava on mushroom tyrosinase activity and melanin formation in mouse B16F10 melanoma cells.
Yoon NY, Eom TK, Kim MM, Kim SK.
J Agric Food Chem. 2009, 57(10), 4124-4129.

Inhibitory efects of triphlorethol-A on MMP-1 induced by oxidative stress in human keratinocytes via ERK and AP-1 inhibition.
Kang KA, Zhang R, Piao MJ, Ko DO, Wang ZH, Lee IK, Kim BJ, Shin T, Park JW, Lee NH, Yoo BS, Hyun JW.
J Toxicol Environ Health. 2008, 7(15), 992-999.

Elastase and hyaluronidase inhibition activities of phlorotannins isolated from Ecklonia cava.
Bu HJ, Ham YM, Kim JM, Lee SJ, Hyun JW, Lee NH.
Kor J Pharmacogn. 2006, 37(2), 92-96.

Photochemoprevention of UVB-induced skin carcinogenesis in SKH-1 mice by brown algae polyphenols.
Hwang H, Chen T, Nines RG, Shin HC, Stoner GD.
Int J Cancer . 2006, 119(12), 2742-2749.

The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts.
Joe MJ, Kim SN, Choi HY, Shin WS, Park GM, Kang DW, Kim YK.
Biol Pharm Bull. 2006, 29(8), 1735-1739.

Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity.
Kim MM, Ta QV, Mendis E, Rajapakse N, Jung WK, Byun HG, Jeon YJ, Kim SK.
Life Sci. 2006, 79(15), 1436-1443.

Tyrosinase inhibitors isolated from the edible brown alga Ecklonia stolonifera.
Kang HS, Kim HR, Byun DS, Son BW, Nam TJ, Choi JS.
Arch Pharm Res. 2004, 27(12), 1226-1232.

The antioxidant activity and tyrosinase inhibitory activity of phlorotannins in Ecklonia cava.
Kim, J.A., Lee, J.M., Shin, D.B. and Lee, N.H.
Food Sci Biotech. 2004, 13(4), 476–480.

Inhibitory activity of brown algal phlorotannins against hyaluronidase.
ShibataT, Fujimoto K, Nagayamak, Yamaguchi K, Nakamura T.
Int J Food Sci Tech. 2002, 37(6), 703-709.