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Inflammation / Joint

Protective Effect of Brown Alga Phlorotannins against Hyper-inflammatory Responses in Lipopolysaccharide-Induced Sepsis Models.
Yang YI, Woo JH, Seo YJ, Lee KT, Lim Y, Choi JH.
J Agric Food Chem. 2016, 64(3), 570-578.

Brown alga Ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress and inflammation by activation of AMPK and SIRT1 in high fat diet-induced obese mice.
Eo H, Jeon YJ, Lee M, Lim Y.
J Agric Food Chem. 2015, 63(1), 349-359.

8,8'-Bieckol, isolated from edible brown algae, exerts its anti-inflammatory effects through inhibition of NF-κB signaling and ROS production in LPS-stimulated macrophages.
Yang YI, Jung SH, Lee KT, Choi JH.
Int Immunopharmacol. 2014, 23, 460-468.

Polyphenol-rich fraction from Ecklonia cava (a brown alga) processing by-product reduces LPS- induced inflammation in vitro and in vivo in a zebrafish model.
Kim SY, Kim EA, Kang MC, Lee, JH, Yang HW, Lee JS, Lim TI, Jeon YJ.
Algae 2014, 29(2), 165-174.

Hemeoxygenase 1 partly mediates the anti-inflammatory effect of dieckol in lipopolysaccharide stimulated murine macrophages.
Yayeh T, Im EJ, Kwon TH, Roh SS, Kim S, Hong SB, Cho JY, Park NH, Rhee MH.
Int Immunopharmacol 2014, 22(1), 51-58.

Suppression of NF-κB by Dieckol Extracted from Ecklonia cava Negatively Regulates LPS Induction of Inducible Nitric Oxide Synthase Gene.
Choi HJ, Park JH, Lee BH, Chee HY, Lee KB, Oh SM.
Appl Biochem Biotechnol. 2014, 173(4), 957-967.

Synthesis of rhodamine-labelled dieckol: its unique intracellular localization and potent anti-inflammatory activity.
Kwak JH, He Y, Yoon B, Koo S, Yang Z, Kang EJ, Lee BH, Han SY, Yoo YC, Lee KB, Kim JS.
Chem Commun (Camb). 2014, 50(86), 13045-13048.

Water soluble sulfated-fucans with immune-enhancing properties from Ecklonia cava.
Cao RA, Lee Y, You S.
Int J Biol Macromol. 2014, 67, 303-311.

Jeju seaweeds suppress lipopolysaccharide-stimulated proinflammatory response in RAW 264.7 murine macrophages.
Yang EJ, Moon JY, Kim SS, Yang KW, Lee WJ, Lee NH, Hyun CG.
Asian Pac J Trop Biomed. 2014, 4(7), 529-537.

Anti-inflammatory effect of fucoidan extracted from Ecklonia cava in zebrafish model.
Lee SH, Ko CI, Jee Y, Jeong Y, Kim M, Kim JS, Jeon YJ.
Carbohydr Polym. 2013, 92(1), 84-89.

Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages.
Jung HA, Jin SE, Ahn BR, Lee CM, Choi JS.
Food Chem Toxicol. 2013, 59, 199-206.

Protective effect of phlorotannins from Eisenia bicyclis against lipopolysaccharide-stimulated inflammation in HepG2 cells.
Kang YM, Eom SH, Kim YM.
Environ Toxicol Pharmacol. 2013, 35(3), 395-401.

The JNk/NFkappaB pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from Ecklonia cava.
Ahn G, Bing SJ, Kang SM, Lee WW, Lee SH, Matsuda H, Tanaka A, Cho IH, Jeon YJ, Jee Y.
Biochim Biophys Acta. 2013, 1830(3), 2820-2829.

Phlorofucofuroeckol A Suppresses Expression of Inducible Nitric Oxide Synthase, Cyclooxygenase-2, and Pro-inflammatory Cytokines via Inhibition of Nuclear Factor-κB, c-Jun NH(2)-Terminal Kinases, and Akt in Microglial Cells.
Kim AR, Lee MS, Choi JW, Utsuki T, Kim JI, Jang BC, Kim HR.
Inflammation. 2013, 36(2), 259-271.

The JNK/NFκB pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from Ecklonia cava.
Ahn G, Bing SJ, Kang SM, Lee WW, Lee SH, Matsuda H, Tanaka A, Cho IH, Jeon YJ, Jee Y.
Biochim Biophys Acta. 2013, 1830(3), 2820-2829.

6,6'-Bieckol, isolated from marine alga Ecklonia cava, suppressed LPS-induced nitric oxide and PGE(2) production and inflammatory cytokine expression in macrophages: The inhibition of NFκB.
Yang YI, Shin HC, Kim SH, Park WY, Lee KT, Choi JH.
Int Immunopharmacol. 2012, 12(3), 510-517.

Anti-inflammatory activities of an ethanol extract of Ecklonia stolonifera in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
Lee MS, Kwon MS, Choi JW, Shin T, No HK, Choi JS, Byun DS, Kim JI, Kim HR.
J Agric Food Chem. 2012, 60(36), 9120-9129.

Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway.
Zhang C, Li Y, Qian ZJ, Lee SH, Li YX, Kim SK.
Evid Based Complement Alternat Med. 2011, 2011, 140462.

Enzymatic Extract from Ecklonia cava Induces the Activation of Lymphocytes by IL-2 Production Through the Classical NF-kappaB Pathway.
Ahn G, Park E, Lee WW, Hyun JW, Lee KW, Shin T, Jeon YJ, Jee Y.
Mar Biotechnol (NY). 2011, 13, 66-73.

Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-κB, Akt, and p38 MAPK.
Kim AR, Lee MS, Shin TS, Hua H, Jang BC, Choi JS, Byun DS, Utsuki T, Ingram D, Kim HR.
Toxicol In Vitro. 2011, 25(8), 1789-1795.

Ecklonia cava extracts inhibit lipopolysaccharide induced inflammatory responses in human endothelial cells
Kim TH, Bae JS.
Food Chem Toxicol. 2010, 48(6), 1682-1687.

Effect of phloroglucinol on oxidative stress and inflammation.
Kim MM, Kim SK.
Food Chem Toxicol. 2010, 48(10), 2925-2933.

Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties.
Kim AR, Shin TS, Lee MS, Park JY, Park KE, Yoon NY, Kim JS, Choi JS, Jang BC, Byun DS, Park NK, Kim HR.
J Agric Food Chem. 2009, 57(9), 3483-3489.

Inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on COX-2 and iNOS in microglial cells.
Jung WK, Heo SJ, Jeon YJ, Lee CM, Park YM, Byun HG, Choi YH, Park SG, Choi IW.
J Agric Food Chem. 2009, 57(10), 4439-4446.

Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-kB pathways.
Jung WK, Ahn YW, Lee SH, Choi YH, Kim SK, Yea SS, Choi I, Park AG, Seo SK, Lee SW, Choi IW.
Food Chem Toxicol. 2009, 47(2), 410-407.

Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: implication for chronic articular disease.
Ryu B, Li Y, Qian ZJ, Kim MM, Kim SK.
Chem Biol Interact . 2009, 179(2-3), 192-201.

An antioxidative and antiinflammatory agent for potential treatment of osteoarthritis from Ecklonia cava.
Shin HC, Hwang HJ, Kang KJ, Lee BH.
Arch Pharm Res. 2006, 29(2), 165-171.

Suppression of iNOS expression by phlorotannins in chronic exposure of skin to UVB radiation.
Hwang H, Chen T, Stoner GD, Lee KB, Yoo YC, Shin HC.
Lab Anim Res. 2005, 21(4), 385-389.

Inhibitory effects of brown algal phlorotannins on secretory phospholipase A2s, lipoxygenases and cyclooxygenases.
Shibata T, Nagayama K, Tanaka R, Yamaguchi K, Nakamura T.
J Appl Phycol. 2003, 15(1), 61-66.